CDEWorld > Courses > Navigating the Whitening Landscape

CE Information & Quiz

Navigating the Whitening Landscape

Sean Pierce, DDS

October 2021 Course - Expires Thursday, October 31st, 2024

Compendium of Continuing Education in Dentistry


Teeth bleaching is a very safe treatment when done properly. Most teeth bleaching techniques use hydrogen peroxide, carbamide peroxide, or a combi-nation of both. Hydrogen peroxide is often used for in-office bleaching, usually at higher concentrations so that patients can achieve faster results. For at-home tray-bleaching options, carbamide peroxide tends to be the preferred compound. Among the many factors to consider to avoid side effects and achieve optimal results, the most important are the hydrogen peroxide concentration of the whitening gel and its contact time on the teeth. The catego-ries of bleaching or whitening procedures and products are in-office, take-home, over-the-counter, and “other.” This article examines the effectiveness, benefits, and potential side effects associated with the available teeth whitening products in these different categories.

You must be signed in to read the rest of this article.

Login Sign Up

Registration on CDEWorld is free. Sign up today!
Forgot your password? Click Here!

 The first reports describing methods for bleaching nonvital teeth appeared in the mid-19th century, when chloride of lime and Labarraque's solution (calcium hydrochlorite and acetic acid) were proposed as potential whitening agents.1,2 In 1885, the first case of teeth bleaching with hydrogen peroxide was reported,3 and in 1918, Dr. C.H. Abbot recorded the first use of a combination of superoxol (30% hydrogen peroxide) with high-intensity light to increase the temperature of the peroxide for the purpose of accelerating the bleaching process.4 Most of the teeth bleaching techniques in use today use hydrogen peroxide as the active ingredient, either directly or as the product of a chemical reaction with other ingredients such as carbamide peroxide,5,6 allowing easy penetration of enamel and dentin owing to their low molecular weights.7

During the teeth-bleaching process, hydrogen peroxide breaks down into water and peroxide radicals (oxygen ions) as it is absorbed through tooth enamel (Figure 1).8 Unstable electrons in these radicals seek to bind with unsaturated double bonds, which are typically dark- or yellow-pigmented, then alter their structure by breaking them down into single carbon bonds and reducing their absorption of light-instead reflecting light and giving teeth a whiter, brighter appearance.7,8


The principal factors influencing the effectiveness of both in-office and take-home whitening treatments are the concentration of hydrogen peroxide and/or carbamide peroxide and the contact times on tooth surfaces.8 In-office bleaching is primarily performed with concentrated solutions of hydrogen peroxide, which breaks down faster and releases a greater number of free radicals owing to its higher concentration of peroxide.8 At-home tray-bleaching solutions most often use carbamide peroxide because of its lower concentration of hydrogen peroxide.8 Carbamide peroxide breaks down more slowly, and it requires longer treatment times than hydrogen peroxide. It is also less effective, but its use in lower concentrations can reduce the likelihood of tooth sensitivity and gum irritation for the patient.8,9


There are two types of tooth staining: intrinsic and extrinsic.8Intrinsic staining is discoloration of the tooth dentin that occurs deeper within the tooth and is caused by genetics, trauma, medications, or environment.8 Overall tooth color can also darken with age as a result of erosion and thinning of the enamel, which becomes more translucent, making the dentin more visible.10

Extrinsic staining is discoloration of the tooth enamel, typically as a result of molecules bonding to bacterial biofilm on the teeth.8This type of staining is usually caused by foods and beverages (eg, wine or coffee), smoking, or poor oral hygiene and is easier to remove than intrinsic staining.8


Teeth bleaching is a safe treatment when performed properly,11and most adverse events are limited to tooth sensitivity and gum irritation.12 However, additional side effects may include soft-tissue burns and erosion of tooth enamel,13,14 cervical resorption, release of selected components of dental restorative materials, and alteration of the enamel surface.15Although studies show that approximately 50% of patients who receive teeth bleaching treatments experience some degree of tooth sensitivity,16 with proper preparation, bleaching techniques, and postprocedural care, this side effect can be reduced or prevented. Chemical burning on intraoral soft tissues from prolonged contact with peroxide can also be minimized or eliminated with proper gingival-isolation training, techniques, and monitoring. The following are the leading considerations for avoiding side effects and achieving successful results with teeth bleaching:

Concentration.  Higer concentrations of hydrogen peroxide in the teeth-bleaching gel whiten teeth more quickly than lower  concentrations.5 However,  the  higher  the  concentration of  hydrogen  peroxide,  the  greater the  likelihood of  side effects and adverse events.17

Contact time. The effectiveness of a teeth-bleaching gel is directly related to its exposure time, with longer contact times corresponding to a greater change in tooth shade.8Again, however, excessive exposure times can cause side effects.8

Temperature. Because temperature accelerates the oxi- dative reaction of peroxide decomposition,8many whitening methods use high-powered lights to increase the temper- ture of the bleaching gel. However, these lights contribute to an increase in pulpal temperatures and damage to healthy tooth structure, as well as desiccation of the teeth, thereby increasing the likelihood of sensitivity and pain both during and after the whitening treatment.8,18

pH. For oxidative effect, the ideal pH for a tooth-bleaching or tooth-whitening gel is 9.5 to 10.8.8 The gels must be shipped and stored at a lower pH to prevent the chemical reaction from occurring before patient use.8 Hydrogen per- oxide and carbamide peroxide have a shelf-life consider- ation because of their oxidative properties.8

Environment. For oxidation that occurs in a sealed environment, the effect of bleaching is optimized by prevent- ing oxygen ions from escaping and oxidases in saliva from neutralizing the free radicals.19


The American Dental Association (ADA) recognizes the following categories of bleaching and/or whitening procedures: in-office bleaching, take-home bleaching, and over-the-counter bleaching or whitening products.20Another category of whitening products is classified as "other," consisting of options that use natural ingredients or ingredients other than hydrogen peroxide and carbamide peroxide. With the exception of the "other" category, all these options rely on the oxidizing effects of hydrogen peroxide or a hydrogen peroxide-releasing agent (ie, carbamide peroxide). However, only in-office and take-home systems are professionally backed by a dentist and performed after an examination and clearance are given.

Over-the-Counter Products

Because of their widespread popularity and easy accessibility, over-the-counter (OTC) whitening products make up the largest and fastest growing category of teeth-whitening procedures.21OTC whitening treatments are widely commercially available in the form of strips, wraps, stock trays, paint-on gels, and more.21These products use hydrogen peroxide or carbamide peroxide but often in much lower concentrations than are used with take-home and in-office treatments.22

The greatest drawback to OTC products is that patients generally do not consult with a dental professional beforehand, and thus there is no opportunity to properly examine and diagnose the patient to ensure whitening is appropriate for the patient per ADA recommendations.23 OTC options rely solely on the patient for proper administration and post-treatment compliance to achieve and maintain results. Examples of OTC products are Crest® 3D Whitestrips® (The Procter & Gamble Company), Opalescence Go® (Ultradent Products, Inc.), and Colgate®(Colgate-Palmolive Company).

"Other" Whitening Options

The "other" category contains a new wave of products for lightening teeth. Products such as coconut oil, charcoal powder, "whitening" toothpastes, and chewing gum whiten or lighten teeth by removing extrinsic stains only. Whitening toothpastes and mouth rinses do not provide adequate contact time to have a dramatic bleaching effect. Overall, methods in the "other" category offer only minimal, fleeting results or are ineffective-and some can even damage tooth enamel.19

Take-Home Bleaching Products

Often referred to as "tray bleaching," take-home bleaching products require a professional dental examination and records to fabricate custom-fitted trays that hold bleaching material.13 Take-home products allow for customized treatment planning for each patient based on their bleaching needs, with the dentist choosing the ideal gel concentration and determining the amount of time required for each treatment.

Several take-home options are currently available. The most important factors to consider are their shelf-life, the contact time, and the patient's susceptibility to sensitivity. If a patient prefers a quick teeth bleaching, a gel containing a high concentration of n hydrogen peroxide would be the product of choice. If the patient has deeper staining, has higher susceptibility of sensitivity, and/or is able to allot more time for bleaching, a gel containing carbamide peroxide would the product of choice.

Opalescence Go (Ultradent Products, Inc.) is a take-home whitening system using prefilled trays containing 10% or 15% hydrogen peroxide to be used for 5 to 10 days.24 The 10% peroxide tray is to be worn for 30 to 60 minutes; the 15% peroxide tray is to be worn for 15 to 20 minutes.24 Pola Office (SDI® Limited) offers a couple of take-home bleaching product options. The Pola Day CP treatment consists of 35% carbamide peroxide to be applied for 15 minutes once or twice per day.25,26 Pola Day offers 7.5% and 9.5% concentrations of carbamide peroxide, to be worn once or twice daily for 30 minutes or once daily for 45 minutes (7.5% concentration) or once daily for 30 minutes (9.5% concentration) during the day.27 Pola Night offers 10%, 16%, and 22% carbamide peroxide concentrations, to be worn for 1 to 2 hours once daily (10% concentration), 90 minutes once daily (16% concentration), or 45 minutes once daily (22% concentration).27

KöR whitening® (Evolve® Dental Technologies) offers KöR-Dayand KöR-Night, a daytime and nighttime at-home whitening treatment under the KöR home brand.28 KöR-Night consists of 16% carbamide peroxide, and its treatment regimen is 2 weeks of at-home nighttime whitening and periodic at-home maintenance.28 KöR-Day is 9% hydrogen peroxide, and its treatment regimen is 2 or more weeks of at-home daytime whitening used once or twice daily and periodic at-home maintenance.28 The daytime treatment is recommended for patients who prefer not to or are unable to wear trays during sleep, or for the patient with high dentin sensitivity who can tolerate wearing whitening trays only for very short periods.28

In-Office Bleaching Products

The most effective option, in-office teeth bleaching offers rapid results and does not rely on patient compliance. The safety of the treatment is directly related to the product that is chosen and to the monitoring that is provided by a licensed dental professional. With a typical hydrogen peroxide concentration range of 20% to 38%, in-office treatments require the use of soft-tissue barriers to prevent chemical burns, and sometimes combine ultraviolet light to increase the temperature of the gel, thus increasing its oxidative capabilities.

The most important considerations when choosing an in-office bleaching system are consistency of results and patient experience. The bleaching system must successfully lighten tooth shade for all patients, with minimal side effects.

Philips® Zoom WhiteSpeed (Koninklijke Philips N.V.) provides light-accelerated whitening, with a hydrogen peroxide concentration of 25%29 and an expected treatment duration of 45 minutes.29,30 GLO (GLO Science, Inc.) is a newer system that features the use of heat and light activation with LED light to accelerate the whitening process.31 Its gels are available in hydrogen peroxide concentrations of 24% and 30%,31 and treatment time is approximately 30 minutes.32With Opalescence Boost (Ultradent Products, Inc.), heat and light are not used and the hydrogen peroxide concentration is 40%.33 Pola Office is a single-use in-office system with a chairtime of approximately 30 minutes and a hydrogen peroxide concentration of 35%.34 The TheraSmile system (Mavrik Dental Systems®) delivers a fully automated teeth whitening treatment.35 With this system, a customized mouthpiece creates a vacuum seal, forming chambers around the teeth through which treatment fluids flow.36 This whitening system provides 360-degree coverage of the treatment area (first molar to first molar) and full-coverage gingival isolation to protect intraoral soft tissues from highly concentrated fluids.35,36


For patients who desire teeth bleaching, selection of a teeth bleaching or teeth whitening procedure or product must take into consideration the needs of the individual patient, including the degree of tooth staining, the patient's susceptibility to side effects such as sensitivity, and the time that the patient has available. Once the patient's needs have been identified, successful results will rely primarily on the concentration of the whitening gel and contact time of the gel on the teeth. Take-home products allow for customized treatment planning for each patient based on their individual requirements. However, although patients may prefer the convenience of take-home bleaching products, in-office teeth bleaching is the most effective option and does not depend on patient compliance. Several in-office bleaching systems are available, which vary in terms of their side effect profile and their whitening effects.


1. Asbell MB. A brief history of orthodontics. Am J Orthod Dentofacial Orthop. 1990;98(3):176-183.

2. Alqahtani MQ. Tooth-bleaching procedures and their controversial effects: a literature review. Saudi Dent J. 2014;26(2):33-46.

3. Harlan AW. The removal of stains from the teeth caused by the administration of medicinal agents and the bleaching of pulpless teeth. JAMA. 1885;IV(5):123-125.

4. Greenwall L. Bleaching techniques in restorative dentistry-an illustrated guide. London, UK: Martin Dunitz Ltd.; 2001.

5. Joiner A. The bleaching of teeth: a review of the literature. J Dent. 2006;34(7):412-419.

6. Hägg G. General and inorganic chemistry. Stockholm: Almqvist and Wiksell Förlag AB; 1969.

7. de Souza GD, Santos LM, Fernandes CA, et al. Sensitivity in dental bleaching and the use of anti-inflammatory agents. JSM Dent.2014;2(1):1023.

8. Levine JB. Teeth-whitening technology. Inside Dentistry.2017;13 (3):42-48.

9. Peixoto AC, Vaez SC, Pereira NAR, et al. High-concentration carbamide peroxide can reduce the sensitivity caused by in-office tooth bleaching: a single-blinded randomized controlled trial. J Appl Oral Sci. 2018;26:e20170573.

10. Algarni AA, Ungar PS, Lippert F, et al. Trend-analysis of dental hard-tissue conditions as function of tooth age. J Dent. 2018;74:107-112.

11. Heymann HO. Tooth whitening: facts and fallacies. Br Dent J. 2005;198(8):514.

12. What are the side effects of teeth whitening? Accessed October 8, 2021.

13. Strassler HE. At-home vital tooth bleaching. Inside Dentistry. 2011;7(2). Accessed October 8, 2021.

14. Demarco FF, Meireles SS, Sarmento HR, Botero T, Tarquinio SB. Erosion and abrasion on dental structures undergoing at-home bleaching. Clin Cosmet Investig Dent. 2011;3:45-52.

15. Goldberg M, Grootveld M, Lynch E. Undesirable and adverse effects of tooth-whitening products: a review. Clin Oral Investig.2010;14(1):1-10.

16. Li Y. Safety controversies in tooth bleaching. Dent Clin North Am. 2011;55(2):255-263.

17. Al-Mansour KA, Al-Qussier AM. The effect of 10% carbamide peroxide bleaching gel on the microhardness of IPS empress direct: an in-vitro study. Pak Oral Dent J. 2015;35(3):504-508.

18. Pace Brinker S. Is light-accelerated whitening worth the pain? Published August 15, 2017. Accessed October 8, 2021.

19. Haywood VB, Caughman WF, Frazier KB, Myers ML. Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. Quintessence Int. 2001;32(2):105-109.

20. American Dental Association. Whitening. Published October 30, 2020. Accessed October 8, 2021.

21. Cardenas AFM, Maran BM, Araújo LCR, et al. Are combined bleaching techniques better than their sole application? A systematic review and meta-analysis. Clin Oral Investig. 2019;23(10):3673-3689.

22. Dionysopoulos D, Papageorgiou S, Malletzidou L, Gerasimidou O, Tolidis K. Effect of novel charcoal-containing whitening toothpaste and mouthwash on color change and surface morphology of enamel. J Conserv Dent.2020;23(6):624-631.

23. American Dental Association. Oral Health Topics: Whitening. Updated October 30, 2020. Accessed October 14, 2021.

24. Opalescence Go. Accessed October 11, 2021.

25. Pola Day CP. [package insert; ISU]. Baywater, VIC, Australia: SDI Limited; 2016. Accessed from Accessed October 14, 2021.

26. Pola Day CP. Accessed October 14, 2021.

27. Pola Day + Pola Night [package insert; ISU]. Baywater, VIC, Australia: SDI Limited; 2020.

28. Kör Whitening. Accessed October 8, 2021.

29. Lee SS, Kwon SR, Ward M, Jenkins W, Souza S, Li Y. A 3 months clinical evaluation comparing two professional bleaching systems of 25% and 40% hydrogen peroxide and extended treatment outcome using a power versus a manual toothbrush. J Esthet Restor Dent. 2019;31(2)-124-131.

30. Philips Zoom WhiteSpeed. Accessed October 11, 2021.

31. GLO Science Professional Dual Whitening System. Dental Advisor website. Accessed October 11, 2021.

32. GLO Chairside Whitening Hardware Kit with Autoclavable Mouthpiece. Accessed October 11, 2021.

33. Opalescence Boost 40% Tooth Whitening System [package insert; IFU US]. South Jordan, UT: Ultradent Products, Inc.

34. Pola office. Accessed October 11, 2021.

35.TheraSmile®whitening machine by Mavrik dental systems®. (n.d.). Accessed October 11, 2021.

36. TheraSmile® oral care automation. Accessed October 11, 2021.

Fig 1. Peroxide breakdown: hydrogen peroxide versus carbamide peroxide. Hydrogen peroxide breakdown produces larger numbers of highly reactive free radicals.6
Reprinted with permission from “Teeth-Whitening Technology” by JB Levine, 2017, Inside Dentistry, 13(3):42-48.

Figure 1

Take the Accredited CE Quiz:

COST: $18.00
SOURCE: Compendium of Continuing Education in Dentistry | October 2021

Learning Objectives:

  • Discuss types and causes of tooth staining and discoloration
  • Describe the effectiveness of hydrogen peroxide versus carbamide peroxide and their respective uses in in-home and take-home teeth bleaching procedures
  • ​Discuss the benefits and disadvantages of available teeth whitening products

Author Qualifications:

Private Practice, Tustin, Irvine, Costa Mesa, CA


The author reports no conflicts of interest associated with this work.

Queries for the author may be directed to